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Many areas of human activity demand high availability (HA) for the services provided by information technology (IT), including supply chain and especially logistics services as its backbone. Logistics automation has already been tightly linked with IT for some time now. Eventually, it is expected to reach a tipping point of digitalization under the Logistics 4.0 concept. Such anticipated convergence provided a basis for the thesis research. It was possible to apply time-proven approaches originally used in IT to produce a tailored and cost-effective HA solution for an ITenabled logistics system in order to minimize costly downtime. A multi-layer architectural pattern was adopted to focus the research on the opportunities to improve HA provided by innovative open-source software. “State-of-the-art” approaches, best practices, and challenges to attaining availability are covered in the course of the thesis. The case study was based on the efforts of a Styrian solution provider for intralogistics systems to improve and standardize HA solution for their software products and services. Mandatory HA requirements to ensure business continuity were used to outline a reference architecture for a generic HA solution by means of HA cluster for a logistics system. A prototype testbed, based on the relevant stack of technologies, validated and evaluated the proposed reference HA architecture. The findings of this thesis demonstrate the feasibility of the idea to build a cost-optimized clusterbased HA solution using commercial off-the-shelf hardware and free open-source software which can deliver an improved level of availability for a modern logistics system.