The importance of alternative fuel concepts is increasing due to environmental and emission regulations. Zero emissions mobility as major purchase intention gives Proton Exchange Membrane fuel cells concepts a significant influence in future vehicle market. The higher demand for PEM-Fuel-Cells necessitates a transformation from small series manufacturing processes to large series producing processes. Especially the unique requisition for proper material and cleanness can significantly influence the lifetime of PEM-Fuel-Cells. The aim of this master’s thesis is to conduct a feasibility study of a serial cleaning process for PEM-Fuel- Cell systems. For this purpose, cleanness requirements are investigated, the state-of-the-art assembling is analysed and then compared with already existing cleaning processes definitions. The conclusions are defined, monitorable and executable cleanness regulations for fuel cell applications. The result of this master’s thesis is a guideline to include a fuel cell cleaning process into a mass assembling process. The investigated allowable ambient conditions and cleanness regulations allow customers the ability to arrange an assembly line to ensure a required durability of fuel cell systems.